Some vapes have as much nicotine as 15+ packs of cigarettes. Nicotine withdrawal symptoms include anxiety and depressed mood, so nicotine dependence may compound stress and mental health symptoms. Get help today: Vaping Just Once Raises Oxidative Stress Levels in Healthy Nonsmokers Increases Disease Risk Study: 'Oxidative Stress' Triggered by Vaping Respiratory Therapy Young people who vape more likely to report chronic stress ERS European Respiratory Society