Evidence that Increased Acetaminophen use in Genetically Vulnerable Children Appears to be a Major Cause of the Epidemics of Autism, Attention Deficit with Hyperactivity, and Asthma Restorative Medicine GSH reduces NAPQI, the metabolite responsible for hepatotoxicity in acetaminophen toxicity. Toxic doses increase oxidation into NAPQI, overwhelming glutathione. How does ethanol interfere with acetaminophen metabolism? Image: https: t.co 6EY9dIwLXY The mechanism of acetaminophen action! The mechanism of action of acetaminophen (paracetamol), a common analgesic, is not yet clear. The study shows that acetaminophen counterintuitively inhibits diacylglycerol lipase (DAGL), but not Tylenol's Impact on Glutathione and Liver Damage