Your Complete Guide to Glutathione Schoenwalder Health & Wellness Identification of cytotoxic, glutathione reactive moieties inducing accumulation of reactive oxygen species via glutathione depletion ScienceDirect Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. Benefits of Glutathione Helps Detox Your Liver And Muc Water for Health