usmle #medstudent #medschool #medicalstudent #medicalstudent Manik Madaan, M.D. 3 Glutathione Rescue Normally, glutathione binds NAPQI and converts it into non toxic byproducts (cysteine + mercapturic acid) that are excreted. Example: Glutathione is your liver's safety net against toxins. Acetaminophen & the kidney Renal Fellow Network Clinical toxicity of Acetaminophen
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napqi and glutathione PXR ribosylation at E194 amplifies NAPQI in acetaminophen‒induced liver injury in mice, rescued by Schisandrin B