Acetaminophen Toxicity: How Genetic Susceptibility Combines with Environmental Factors Le glutathion Mdecine Intgre Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. Oxidative stress mediates end organ damage in a novel model of acetaminophen toxicity in Drosophila Scientific Reports