Oral Melanotic Macule: Symptoms and Treatment Skinsight Melanotic macule. Benign. Dark spot on labia (or lip). Analogous to lentigo simplex. Hyperpigmented basal keratinocytes & dermal melanophages. Slight in single basal melanocytes; NO nests. More info like this in Mucosal melanocytic macules This patient has multiple labial melanotic macules. These are essentially freckles of the lips. These most commonly involve the lower lip. This patient had involvement of both the upper and lower lips.
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labial melanotic macule vs melanoma Figure 1 from Dermoscopy of venous lake on the lips: A comparative study with labial melanotic macule