In patients with liver disease, acetaminophen metabolism is altered: the half life may be prolonged, and glutathione stores may be reduced, Therefore, acetaminophen can be used safely at reduced doses Cirrhosis happens when long term inflammation leads to permanent scarring in the liver, making it harder for this vital organ to perform its 500+ daily functions. There are two stages, compensated and decompensated Lipoic acid in metabolic dysfunction associated steatotic liver disease: a review Nutrition & Metabolism Springer Nature Link Frontiers Commonly encountered symptoms and their management in patients with cirrhosis