G6PD Deficiency Glucose 6 phosphate dehydrogenase deficiency X linked recessive disorder Leads to low NADPH, impairing glutathione regeneration RBCs are vulnerable to oxidative damage Pathophysiology: In G6PD deficiency: No Clinical associations and potential cellular mechanisms linking G6PD deficiency and atherosclerotic cardiovascular disease npj Metabolic Health and Disease Clinical Pharmacology & Toxicology Pearl of the Week Glucose 6 phosphate dehydrogenase deficiency The Lancet