View of Acetaminophen, the missing anion gap in the patient with metabolic acidosis The Southwest journal of medicine A study published in Gastroenterology describes a new mitochondrial mediator in the hepatotoxicity induced by paracetamol. Institute of Biomedical Research of Barcelona Glutathione Depletion in Mitochondrial Diseases Glutathione Reporter Too much paracetamol = dangerous because of how your liver processes it. *Normal dose:* About 90 95% gets broken down safely by glucuronidation + sulfation non toxic stuff you pee out. *The problem