Clinical associations and potential cellular mechanisms linking G6PD deficiency and atherosclerotic cardiovascular disease npj Metabolic Health and Disease A small molecule G6PD inhibitor reveals immune dependence on pentose phosphate pathway Nature Chemical Biology In G6PD deficiency (XR), we have increased oxidative damage to RBCs, leading to intravascular hemolysis with decreased serum haptoglobin. We have decreased NADPH production, which means decreased conversion of oxidized ( S S ) glutathione Blister Cell in G6PD Deficiency , Red Blood Cell with a clear vacuole like area on its membrane, resembling a blister., It usually results when splenic macrophages remove precipitated Heinz