Paracetamol (Acetaminophen) Poisoning IntechOpen Acetaminophen and aspirin toxicity are both high yield, but the injury pattern is very different. Acetaminophen overdose overwhelms glutathione, allowing NAPQI to build up and cause hepatic necrosis. The antidote is N acetylcysteine, which Coptidis Rhizoma Alkaloids Alleviate Acetaminophen Induced Liver Injury by Regulating GSH Metabolism and the TNF Signaling Pathway 5 Antidote: NAC (N acetylcysteine) NAC replenishes glutathione, restoring the ability to detoxify NAPQI. It's lifesaving if given early. Example: Hospitals use NAC as the standard treatment for APAP overdose.