Melanotic Macules, Naevi, and Melanoma Springer Nature Link ORAL MELANOSIS leading to the diagnosis of HIV infection. Despite being a weak association, any unexplained oral pigmentation in a high risk individual should make one suspect HIV associated oral melanosis and proceed Happy Wednesday! , In this video, a patients labial melanotic macule (a benign pigmented lesion) is being treated with liquid nitrogen. Labial melanotic macules are flat and asymmetrical with a Oral pathology: Noting a pigmented macule that often presents a diagnostic dilemma Registered Dental Hygienists