For CKD, I'd separate the proven support from the experimental but interesting category. Astragalus root extract is probably the most tried and true natural compound I'd look at first. There's actual human data showing Glutathione specific gammaglutamylcyclotransferase 1 (CHAC1) increases kidney disease risk by modulating ferroptosis Science Translational Medicine Glutathione, NAC & Vitamin C 30 Veg caps Glutathione, NAC & Vitamin C APOL1 Renal Risk Variants and Sickle Cell Trait Associations With Reduced Kidney Function in a Large Congolese Population Based Study Kidney International Reports
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glutathione or nac better Metabolic Homeostasis of Amino Acids and Diabetic Kidney Disease