Acetaminophen or Tylenol Toxicity Lect 19 Pharmacology Frontiers Paracetamol Induced Glutathione Consumption: Is There a Link With Severe COVID 19 Illness? Acetaminophen toxicity EMCrit Project Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors.