Carnitine, Acylcarnitines and Beta Oxidation Short Note On Carnitine Shuttle: Fatty acids are oxidized in mitochondria, and synthesized in the cytoplasm. Long chain fatty acids must form an active intermediate, fatty acyl CoA, before being oxidized inside mitochondria. Catherine Figure 1 from Translating the basic knowledge of mitochondrial functions to metabolic therapy: role of L carnitine. Semantic Scholar The Importance of the Fatty Acid Transporter L Carnitine in Non Alcoholic Fatty Liver Disease (NAFLD)