The organic arsenical derived thioredoxin and glutathione system inhibitor ACZ2 induces apoptosis and autophagy in gastric cancer via ROS dependent ER stress ScienceDirect We are all being exposed to heavy metals. Through food, water, cookware, dental materials, and the air we breathe. The question isn't IF you have heavy metal exposure, it's how well your Glutathione S transferase Theta 2 causes drug resistance by inhibiting arsenic trioxide induced ferroptosis in pancreatic ductal adenocarcinoma ScienceDirect Toxicity of Glutathione Binding Metals: A Review of Targets and Mechanisms