Tylenol Avoid or Not to Avoid? Acetaminophen (Tylenol) can deplete glutathione, your body's most important detox antioxidant. This matters even more if your child has an MTHFR gene mutation, which g glutamyl cycle. Depletion of glutathione by acetaminophen leads to Download Scientific Diagram Does Acetaminophen Deplete Glutathione? Understanding the Connection Cymbiotika CYMBIOTIKA Glutathione: Master Antioxidant, Reducing Oxidative Stress, and Detoxification