Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. Acetaminophen C8H9NO2 CID 1983 PubChem Frontiers Multiscale zonation resolved modeling of dose dependent determinants of acetaminophen induced liver injury Glutathione, Tylenol & Your Health: What You Should Know
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