Understanding Glutathione Deficiency Invigor Medical Signs You Might Be Low on Glutathione in Athletic Performance and How IV Therapy Could Make a Difference Glutathione deficiency can lead to a variety of signs and symptoms that affect your overall health. Here are some common signs to look out for: 1. **Increased Dark Spots** Glutathione Figure 1 from Dossier : Oxidative stress pathologies and antioxidants The importance of glutathione in human disease Semantic Scholar