Mystery behind labial and oral melanotic macules: Clinical, dermoscopic and pathological aspects of Laugier Hunziker syndrome Tiny brown spot on the lip? Don't ignore it. A melanotic macule is a small, well circumscribed brown to black oral lesion most commonly seen on the lower lip and a high yield ADC exam favourite. Oral Malignant Melanoma Oral Cancer Foundation Information and Resources about Oral Head and Neck Cancer What Caused These Multiple Hyperpigmented Macules of the Mouth?