I'm taking NAC and glutathione as per my OAT and other testing says I need. Yet it makes me depressed. Anyone know why ? NAcetylcysteine (NAC) is More Than Just an Antidote. NAC replenishes glutathione (GSH), breaks mucus disulfide bonds, and modulates glutamate. That's why it works in the liver, lungs, and brain. Owais Glutathione metabolism in cardiac ferroptosis. N acetylcysteine or Download Scientific Diagram Glutathione Precursor, N Acetyl Cysteine, Improves Mismatch Negativity in Schizophrenia Patients Neuropsychopharmacology