Natural red hair color is primarily caused by variants in the MC1R (melanocortin 1 receptor) gene, which regulates melanin production in the body. These variants favor the production of reddish yellow pheomelanin over Reduced MC4R signaling alters nociceptive thresholds associated with red hair Science Advances Melanotan 2 For Hair Color Change? : r Melanotan2 Superpower
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