Frontiers Gut Metabolite Trimethylamine N Oxide in Atherosclerosis: From Mechanism to Therapy TMAO and Heart Disease A Serious Heart Marker Functional Medicine University The Leader in Online Training in Functional Diagnostic Medicine Simultaneous quantification of trimethylamine oxide and its precursors from gut microbial metabolic pathway Trimethylamine N oxide (TMAO) is a small molecule produced in humans primarily by the gut liver axis and has become an important biomarker, and possible mediator, of cardiometabolic and renal disease. Dietary choline, phosphatidylcholine (
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