Frontiers Aerosolized nicotine from e cigarettes alters gene expression, increases lung protein permeability, and impairs viral clearance in murine influenza infection The evidence is clear: Young E cigarette users suffer from respiratory symptoms American Lung Association Frontiers Chronic E Cigarette Aerosol Inhalation Alters the Immune State of the Lungs and Increases ACE2 Expression, Raising Concern for Altered Response and Susceptibility to SARS CoV 2 E cigarette aerosol exacerbates cardiovascular oxidative stress in mice with an inactive aldehyde dehydrogenase 2 enzyme ScienceDirect