Using nicotine based vapes is likely to cause lung and oral cancer, even if e cigarette users do not smoke tobacco, a watershed academic review has found. Disturbing Trends with E Cigarettes in Schools E cigarettes are not a healthier alternative to cigarettes. They contain nicotine and many harmful ingredients that can cause cancer and heart disease. Since these products are relatively new, we don't know all E cigarette users show cancer linked genetic changes TRDRP