Does Smoking Constrict Your Blood Vessels? Peripheral artery disease (PAD) is the narrowing or blockage of blood vessels that run from the heart to other parts of the body. Smoking can cause PAD. Quit smoking to protect your Knowing your risk factors for stroke can save your life. High blood pressure, smoking, and inactivity increase stroke riskbut many factors can be managed through prevention and healthy lifestyle changes. If you Pod based e cigarettes versus combustible cigarettes: The impact on peripheral and cerebral vascular function and subjective experiences